Affordable Access

deepdyve-link
Publisher Website

European evidence-based recommendations for the diagnosis and treatment of childhood-onset lupus nephritis: the SHARE initiative.

Authors
  • Groot, Noortje1, 2
  • de Graeff, Nienke1
  • Marks, Stephen D3
  • Brogan, Paul3
  • Avcin, Tadej4
  • Bader-Meunier, Brigitte5
  • Dolezalova, Pavla6
  • Feldman, Brian M7
  • Kone-Paut, Isabelle8
  • Lahdenne, Pekka9
  • McCann, Liza10
  • Özen, Seza11
  • Pilkington, Clarissa A3
  • Ravelli, Angelo12
  • Royen-Kerkhof, Annet van1
  • Uziel, Yosef13
  • Vastert, Bas J1
  • Wulffraat, Nico M1
  • Beresford, Michael W10, 14
  • Kamphuis, Sylvia2
  • 1 Wilhelmina Children's Hospital, Utrecht, The Netherlands. , (Netherlands)
  • 2 Sophia Children's Hospital, Erasmus University Medical Center, Rotterdam, The Netherlands. , (Netherlands)
  • 3 Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
  • 4 University Children's Hospital Ljubljana, Ljubljana, Slovenia. , (Slovenia)
  • 5 Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France. , (France)
  • 6 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic. , (Czechia)
  • 7 Division of Rheumatology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. , (Canada)
  • 8 Bicêtre Hospital, Paris, APHP, University of Paris Sud, Paris, France. , (France)
  • 9 Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland. , (Finland)
  • 10 Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
  • 11 Department of Pediatrics, Hacettepe University, Ankara, Turkey. , (Turkey)
  • 12 Università degli Studi di Genova and Istituto Giannina Gaslini, Genoa, Italy. , (Italy)
  • 13 Meir Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel. , (Israel)
  • 14 Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Type
Published Article
Journal
Annals of the Rheumatic Diseases
Publisher
BMJ
Publication Date
Dec 01, 2017
Volume
76
Issue
12
Pages
1965–1973
Identifiers
DOI: 10.1136/annrheumdis-2017-211898
PMID: 28877866
Source
Medline
Keywords
License
Unknown

Abstract

Lupus nephritis (LN) occurs in 50%-60% of patients with childhood-onset systemic lupus erythematosus (cSLE), leading to significant morbidity. Timely recognition of renal involvement and appropriate treatment are essential to prevent renal damage. The Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) initiative aimed to generate diagnostic and management regimens for children and adolescents with rheumatic diseases including cSLE. Here, we provide evidence-based recommendations for diagnosis and treatment of childhood LN. Recommendations were developed using the European League Against Rheumatism standard operating procedures. A European-wide expert committee including paediatric nephrology representation formulated recommendations using a nominal group technique. Six recommendations regarding diagnosis and 20 recommendations covering treatment choices and goals were accepted, including each class of LN, described in the International Society of Nephrology/Renal Pathology Society 2003 classification system. Treatment goal should be complete renal response. Treatment of class I LN should mainly be guided by other symptoms. Class II LN should be treated initially with low-dose prednisone, only adding a disease-modifying antirheumatic drug after 3 months of persistent proteinuria or prednisone dependency. Induction treatment of class III/IV LN should be mycophenolate mofetil (MMF) or intravenous cyclophosphamide combined with corticosteroids; maintenance treatment should be MMF or azathioprine for at least 3 years. In pure class V LN, MMF with low-dose prednisone can be used as induction and MMF as maintenance treatment. The SHARE recommendations for diagnosis and treatment of LN have been generated to support uniform and high-quality care for all children with SLE.

Report this publication

Statistics

Seen <100 times