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ETS-related gene (ERG) undermines genome stability in mouse prostate progenitors via Gsk3β dependent Nkx3.1 degradation

Authors
  • Lorenzoni, Marco
  • De Felice, Dario
  • Beccaceci, Giulia
  • Di Donato, Giorgia
  • Foletto, Veronica
  • Genovesi, Sacha
  • Bertossi, Arianna
  • Cambuli, Francesco
  • Lorenzin, Francesca
  • Savino, Aurora
  • Avalle, Lidia
  • Cimadamore, Alessia
  • Montironi, Rodolfo
  • Weber, Veronica
  • Carbone, Francesco Giuseppe
  • Barbareschi, Mattia
  • Demichelis, Francesca
  • Romanel, Alessandro
  • Poli, Valeria
  • Del Sal, Giannino
    • And 4 more
Type
Published Article
Journal
Cancer letters
Publication Date
May 28, 2022
Volume
534
Identifiers
DOI: 10.1016/j.canlet.2022.215612
PMID: 35259458
PMCID: PMC8968219
Source
PubMed Central
Keywords
Disciplines
  • Original Articles
License
Unknown

Abstract

• Expression of ERGM40 in mouse prostate organoids promotes their survival and growth in the absence of Egf. • ERGM40 alters the extracellular signaling network of mouse prostate organoids. • Canonical Wnt pathway is substantially reduced in ERG + prostate organoids due to decreased autocrine signaling of Wnt4. • Gsk3b promotes Nkx3.1 proteolysis and, in turn, accumulation of double strand breaks in ERG + prostate organoids. • Paracrine signaling of ERG + prostate organoids modulates Arginase 1 expression in M1-polarized macrophages.

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