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Etoricoxib and Diclofenac Might Reduce the Risk of Dementia in Patients with Osteoarthritis: A Nation-Wide, Population-Based Retrospective Cohort Study

Authors
  • Xue, Yu-Hao
  • Peng, Yu-Shin
  • Ting, Hsin-Fu
  • Peijer Hsieh, Jason
  • Huang, Yu-Kai
  • Wang, Yu-Hsun
  • Chiou, Jeng-Yuan
  • Wei, James Cheng-Chung
Type
Published Article
Journal
Dementia and Geriatric Cognitive Disorders
Publisher
S. Karger AG
Publication Date
Jun 28, 2018
Volume
45
Issue
5-6
Pages
262–271
Identifiers
DOI: 10.1159/000485176
PMID: 29953974
Source
Karger
Keywords
License
Green
External links

Abstract

Introduction: This population-based cohort study investigates the association between osteoarthritis (OA) and dementia as well as the connection between NSAIDs and dementia. Methods: We chose the samples from the Taiwan Longitudinal Health Insurance Database and then divided them into two groups, which were then matched 1: 1 by propensity score. The first group was the OA group that contained patients with newly diagnosed OA and the second group was the non-OA group. We used the χ2 test, Student t test, Kaplan-Meier analysis, and Cox proportional hazard model for different purposes. Results: The prevalence of dementia in the OA group was higher than that in the non-OA group. The adjusted hazard ratio of the former was 1.42 (95% CI, 1.30–1.54). We also found that etoricoxib and diclofenac might reduce the incidence of dementia. Conclusion: Patients with OA might have a higher risk of dementia. Both etoricoxib and diclofenac might lower the risk of dementia in patients with OA.

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