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Etiology and impact on outcomes of polycystic kidney disease in abdominal aortic aneurysm

Authors
  • Nakano, Mitsunori1
  • Kimura, Naoyuki1
  • Nonaka, Takao1
  • Mieno, Makiko2
  • Tanno, Keisuke3
  • Sasabuchi, Yusuke2
  • Kitada, Yuichiro1
  • Hori, Daijiro1
  • Yuri, Koichi1
  • Matsumoto, Harunobu1
  • Yamaguchi, Atsushi1
  • Hanaoka, Kazushige4
  • 1 Jichi Medical University, 1-847 Amanumacho, Omiya-ward, Saitama, 330-8503, Japan , Omiya-ward, Saitama (Japan)
  • 2 Jichi Medical University, Shimotsuke, 329-0498, Japan , Shimotsuke (Japan)
  • 3 Jichi Medical University, Saitama, 330-0834, Japan , Saitama (Japan)
  • 4 The Jikei University, Tokyo, 105-8461, Japan , Tokyo (Japan)
Type
Published Article
Journal
Surgery Today
Publisher
Springer Singapore
Publication Date
Apr 06, 2020
Volume
50
Issue
10
Pages
1213–1222
Identifiers
DOI: 10.1007/s00595-020-01997-6
Source
Springer Nature
Keywords
License
Yellow

Abstract

PurposeWe investigated the etiology and impact on outcomes of polycystic kidney disease in patients with abdominal aortic aneurysm.MethodsEight-hundred patients who underwent open (n = 603) or endovascular aortic repair (n = 197) were divided into three groups: no cyst (n = 204), non-polycystic kidney (n = 503), and polycystic kidney (≥ 5 cysts in the bilateral kidneys, n = 93). The characteristics and outcomes were compared among the groups.ResultsIn the polycystic kidney group, the age was increased and the proportions of patients with male sex, hypertension, and estimated glomerular filtration rate < 30 mL/min/1.73 m2 were greater. The overall hospital mortality rates were similar. The incidence of acute kidney injury after elective open aortic repair was increased in the polycystic kidney group (12%, 17%, and 29%, P = 0.020). In the polycystic kidney group, 80 patients did not have renal enlargement or a family history of renal disease, while 13 (corresponding to 1.6% [13/800] of the overall patients), had renal enlargement, suggesting the possibility of hereditary polycystic kidney disease.ConclusionsIn our cohort, 1.6% of the patients with abdominal aortic aneurysm who underwent surgery were at risk of hereditary polycystic kidney disease. Polycystic kidney disease was associated with acute kidney injury after open aortic repair.

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