Affordable Access

[Etiology of Alzheimer's disease].

Authors
  • Wöber, C
  • Dal-Bianco, P
  • Hufgard, J
  • Lind, C
  • Deecke, L
Type
Published Article
Journal
Der Nervenarzt
Publication Date
Feb 01, 1992
Volume
63
Issue
2
Pages
74–81
Identifiers
PMID: 1565172
Source
Medline
License
Unknown

Abstract

The major factor that causes problems in studies on the aetiology of Alzheimer's disease (AD) is the clinical heterogeneity of the condition. Familial early-onset AD and familial late-onset AD are differentiated from sporadic AD. Aetiologically a genetic defect on chromosome 21 is the most important factor, at least in some cases of AD. In familial AD and autosomal dominant inheritance with complete penetrance in old age is thought to be possible. In sporadic AD the role of genetic and exogenous factors (infectious agents, aluminium) is unknown. The current status of knowledge about the aetiology of Alzheimer's disease is reviewed with reference to the literature.

Report this publication

Statistics

Seen <100 times