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Ethics in Translational Gene Transfer Research

Authors
  • Hyun, Insoo
  • Kimmelman, Jonathan
Type
Book
Journal
Gene Therapy of Cancer
Publication Date
Jan 01, 2014
Pages
517–526
Identifiers
DOI: 10.1016/B978-0-12-394295-1.00036-6
ISBN: 978-0-12-394295-1
Source
Elsevier
Keywords
License
Unknown

Abstract

The clinical translation of anticancer gene transfer research raises ethical questions not adequately addressed by the basic framework of research regulation. These ethical challenges involve (1) knowing when to transition from preclinical to clinical research, (2) how to think about trial design, and (3) how to enroll patient subjects while avoiding therapeutic misconception and misestimation. Important ethical questions in each of these areas call into action a core set of ethical values underscoring all biomedical research.

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