Affordable Access

deepdyve-link
Publisher Website

Ethanol-induced mast cell-mediated inflammation leads to increased susceptibility of intestinal tumorigenesis in the APC Δ468 min mouse model of colon cancer.

Authors
  • Wimberly, Andre L
  • Forsyth, Christopher B
  • Khan, Mohammad W
  • Pemberton, Alan
  • Khazaie, Khashayarsha
  • Keshavarzian, Ali
Type
Published Article
Journal
Alcoholism Clinical and Experimental Research
Publisher
Wiley (Blackwell Publishing)
Publication Date
Jan 01, 2013
Volume
37 Suppl 1
Identifiers
DOI: 10.1111/j.1530-0277.2012.01894.x
PMID: 23320800
Source
Medline
License
Unknown

Abstract

Our data show that chronic alcohol intake promotes: (i) intestinal tumorigenesis and tumor invasion in genetically susceptible mice; (ii) increases in polyp-associated mast cells; and (iii) mast cell-mediated tumor migration in vitro. Both our in vivo and in vitro studies suggest that mast cell-mediated inflammation could be 1 mechanism by which alcohol promotes carcinogenesis.

Report this publication

Statistics

Seen <100 times