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Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay.

Authors
  • D Miller
  • B B Wheals
  • N Beresford
  • J P Sumpter
Publication Date
Feb 01, 2001
Source
PMC
Keywords
License
Unknown

Abstract

We used a recombinant yeast estrogen assay to assess the activity of 73 phenolic additives that are used as sunscreens, preservatives, disinfectants, antioxidants, flavorings, or for perfumery. Thirty-two of these compounds displayed activity: 22 with potencies relative to 17beta-estradiol, ranging from 1/3,000 to < 1/3,000,000, and 10 compounds with an impaired response that could not be directly compared with 17beta-estradiol. Forty-one compounds were inactive. The major criteria for activity appear to be the presence of an unhindered phenolic OH group in a para position and a molecular weight of 140-250 Da.

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