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Estrogen is renoprotective via a nonreceptor-dependent mechanism after cardiac arrest in vivo.

Authors
  • Hutchens, Michael P
  • Nakano, Takaaki
  • Kosaka, Yasuharu
  • Dunlap, Jennifer
  • Zhang, Wenri
  • Herson, Paco S
  • Murphy, Stephanie J
  • Anderson, Sharon
  • Hurn, Patricia D
Type
Published Article
Journal
Anesthesiology
Publication Date
Feb 01, 2010
Volume
112
Issue
2
Pages
395–405
Identifiers
DOI: 10.1097/ALN.0b013e3181c98da9
PMID: 20068453
Source
Medline
License
Unknown

Abstract

In women, kidneys were protected from cardiac arrest through estrogen. Estradiol-mediated renoprotection was not affected by ER deletion or blockade. Estradiol is renoprotective after cardiac arrest. The results indicate that estradiol renoprotection is ER-[alpha] and ER-[beta] independent.

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