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Estrogen receptor mutations in breast cancer--new focus on an old target.

Authors
  • Segal, Corrinne V
  • Dowsett, Mitch
Type
Published Article
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Publication Date
Apr 01, 2014
Volume
20
Issue
7
Pages
1724–1726
Identifiers
DOI: 10.1158/1078-0432.CCR-14-0067
PMID: 24583794
Source
Medline
License
Unknown

Abstract

Recent studies have provided strong evidence for the emergence of substantial numbers of constitutively active ESR1 mutations in estrogen receptor-positive metastatic breast cancer that are undetected in primary disease. Some of these mutants remain partially sensitive to current anti-estrogen therapies but effective therapeutics targeted at them may require new approaches.

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