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Estrogen Modulates Glycerol Permeability in Sertoli Cells through Downregulation of Aquaporin-9

Authors
  • Bernardino, Raquel L.
  • Carrageta, David F.
  • Silva, Ana M.
  • Calamita, Giuseppe
  • Alves, Marco G.
  • Soveral, Graça
  • Oliveira, Pedro F.
Publication Date
Sep 28, 2018
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

permeability to glycerol, while downregulating AQP9 expression, thus suggesting a novel mechanism by which E2 modulates fluid secretion in the testis. In conclusion, E2 is an important regulator of mSCs physiology and secretion through changes in AQP9 expression and function. Thus, alterations in glycerol permeability induced by E2 may be the cause for male infertility in cases associated with the presence of high E2 levels.

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