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Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model

  • Jeong, Hyemin1
  • Bae, Eun-Kyung2
  • Kim, Hunnyun2
  • Eun, Yeong Hee3
  • Kim, In Young3
  • Kim, Hyungjin3
  • Lee, Jaejoon3
  • Jeon, Chan Hong1
  • Koh, Eun-Mi3
  • Cha, Hoon-Suk3
  • 1 Soonchunhyang University Hospital, Division of Rheumatology, Department of Internal Medicine, Bucheon, South Korea , Bucheon (South Korea)
  • 2 Samsung Biomedical Research Institute, Seoul, South Korea , Seoul (South Korea)
  • 3 Sungkyunkwan University School of Medicine, Division of Rheumatology, Department of Internal Medicine, Samsung Medical Center, 81 Irwon-Ro, Gangnam-gu, Seoul, 06351, South Korea , Seoul (South Korea)
Published Article
Arthritis Research & Therapy
Springer Science and Business Media LLC
Publication Date
Sep 07, 2017
DOI: 10.1186/s13075-017-1407-9
Springer Nature


BackgroundAnkylosing spondylitis (AS) is a male-predominant disease, and radiographic evidence of damage is also more severe in males. Estrogen modulates immune-related processes such as T cell differentiation and cytokine production. This study aimed to evaluate the effect of estrogen on the disease activity of spondyloarthritis (SpA).MethodsThe effects of estrogen on the development of arthritis were evaluated by performing ovariectomy and 17β-estradiol (E2) pellet implantation in zymosan-treated SKG mice. Clinical arthritis scores were measured, and 18F-fluorodeoxyglucose (18F-FDG) small-animal positron emission tomography/computed tomography performed to quantify joint inflammation. The expression of inflammatory cytokines in joint tissue was measured.ResultsE2-treated mice showed remarkable suppression of arthritis clinically and little infiltration of inflammatory cells in the Achilles tendon and intervertebral disc. 18F-FDG uptake was significantly lower in E2-treated mice than in sham-operated (sham) and ovariectomized mice. Expression of TNF, interferon-γ, and IL-17A was significantly reduced in E2-treated mice, whereas expression of sclerostin and Dickkopf-1 was increased in E2-treated mice compared with sham and ovariectomized mice.ConclusionsEstrogen suppressed arthritis development in SKG mice, a model of SpA. Results of this study suggest that estrogen has an anti-inflammatory effect on the spondyloarthritis manifestations of the SKG arthritis model.

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