These studies have established a body of evidence on Xingxue SXN safety, and provide a good model for Chinese medicine injection for clinical safety. The Xingxue SXN production process and toxicology research indicate the safety of the injection. However, the use of the injection is not consistent with instructed clinical practice. Xingxue SXN causes ADRs perhaps from inappropriate usage or its pharmacological action. This injection needs better RiskMAPs to ensure its clinical safety.