We examined some conditions under which a response acquired as a tact might facilitate the establishment of a mand. We taught 3 participants with developmental disabilities to tact the items ranked highest and lowest in a preference assessment and subsequently tested to see if the responses occurred as mands. All participants manded for the highly preferred item but rarely manded for the nonpreferred item. These results indicate that, although tact and mand functions are different, conditions can be created to facilitate transfer from the former to the latter. Implications for communication training are discussed.