Affordable Access

Establishment and characterization of human malignant pleural mesothelioma cell line SMC-1.

Authors
  • Wu, S F
  • Wang, E Z
  • Su, J Z
  • Xu, H X
  • Lin, Z Q
  • Sheng, C F
  • Xu, C W
  • Chen, R M
  • Ye, X Z
  • Zhu, D H
Type
Published Article
Journal
Scientia Sinica. Series B, Chemical, biological, agricultural, medical & earth sciences / Chung-kuo k'o hsüeh yüan, chu pan
Publication Date
Mar 01, 1985
Volume
28
Issue
3
Pages
281–288
Identifiers
PMID: 3159086
Source
Medline
License
Unknown

Abstract

A cell line (SMC-1) has been established from the resected tissue of a patient with malignant pleural mesothelioma which has been pathologically confirmed to be the mixed type. The cell line is characterized by the pleomorphy and multilayered growth of the cells with the population-doubling time of approximately 32 h, the highest mitotic index of 46--50% and the modal chromosome number of 69-70. Transplantation of the cells into the animals can produce tumors bearing histological resemblance to the original material. The cultured cells, xenografted tumor cells and the cells from the host specimen show similar histochemical expressions. These data meet the requirements of a human malignant pleural mesothelioma cell line. The establishment of this cell line will serve as a useful tool in clinical research of diagnosis and treatment of this devastating disease.

Report this publication

Statistics

Seen <100 times