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[Establishment and characterization of doxorubicin-resistant BGC-823/DOX of human gastric cancer cell line].

Authors
  • Zheng, G
  • Liu, X
  • Han, F
Type
Published Article
Journal
Zhonghua wai ke za zhi [Chinese journal of surgery]
Publication Date
May 01, 1997
Volume
35
Issue
5
Pages
262–264
Identifiers
PMID: 10374555
Source
Medline
License
Unknown

Abstract

To study drug resistance mechanism of gastrointestinal tumor, doxorubicin resistant cell line of human gastric cancer, we developed BGC-823/DOX, by increasing doses of doxorubicin. We completed chromosomal analysis, double time of cell grow, cell cycle distributions, drug resistance and cross-resistance, and studied reversing drug resistance. The results showed that chromosome of BGC-823/DOX was subtriploid karyotype. Cell morphology, double time, cell cycle distributions were different from its parent cells and 6.35 times more resistant to cytotoxic action of doxorubicin, cross-resistant to VP-16. Verapamil showed modified effect on doxorubicin resistance. BGC-823/DOX with doxorubicin resistance has many characteristics of gastrointestinal tumors.

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