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Establishing pathological cut-offs of brain atrophy rates in multiple sclerosis.

Authors
  • De Stefano, Nicola1
  • Stromillo, Maria Laura1
  • Giorgio, Antonio1
  • Bartolozzi, Maria Letizia2
  • Battaglini, Marco1
  • Baldini, Mariella2
  • Portaccio, Emilio3
  • Amato, Maria Pia3
  • Sormani, Maria Pia4
  • 1 Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy. , (Italy)
  • 2 Neurology Unit, Hospital of Empoli, Empoli, Italy. , (Italy)
  • 3 Department of Neurology, University of Florence, Florence, Italy. , (Italy)
  • 4 Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy. , (Italy)
Type
Published Article
Journal
Journal of Neurology Neurosurgery & Psychiatry
Publisher
BMJ
Publication Date
Jan 01, 2016
Volume
87
Issue
1
Pages
93–99
Identifiers
DOI: 10.1136/jnnp-2014-309903
PMID: 25904813
Source
Medline
Keywords
License
Unknown

Abstract

Our evidence-based criteria provide values able to discriminate the presence or absence of 'pathological' brain volume loss in MS with high specificity. Such results could be of great value in a clinical setting, particularly in assessing treatment efficacy in MS.

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