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Essential role for Max in early embryonic growth and development

Authors
  • Hong Shen-Li
  • Rónán C. O'Hagan
  • Harry Hou
  • James W. Horner
  • Han-Woong Lee
  • Ronald A. DePinho
Publisher
Cold Spring Harbor Laboratory Press
Publication Date
Jan 01, 2000
Source
PMC
Keywords
Disciplines
  • Medicine
License
Unknown

Abstract

Loss of Max function in the mouse resulted in generalized developmental arrest of both embryonic and extraembryonic tissues at early postimplantation (∼E5.5–6.5), coincident with loss or dilution of maternal Max stores in the expanding embryo in vivo and in blastocyst outgrowths in vitro. Developmentally arrested embryos were reduced in size and exhibited widespread cytological degeneration and feeble BrdU incorporation. Max and, by extension, the Myc superfamily, serve essential roles in early mammalian development and a maternal reservoir of Max exists in sufficient amount to sustain Myc superfamily function through preimplantation stages of development.

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