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Essential role of the CCL2–CCR2 axis in Mayaro virus-induced disease

Authors
  • Santos, Franciele Martins
  • Costa, Victor Rodrigues de Melo
  • Araújo, Simone de
  • Sousa, Carla Daiane Ferreira de
  • Moreira, Thaiane Pinto
  • Gonçalves, Matheus Rodrigues
  • Santos, Anna Clara Paiva Menezes dos
  • Ferreira, Heloísa Athayde Seabra
  • Costa, Pedro Augusto Carvalho
  • Barrioni, Breno Rocha
  • Bargi-Souza, Paula
  • Pereira, Marivalda de Magalhães
  • Nogueira, Maurício Lacerda
  • Souza, Danielle da Glória
  • Guimarães, Pedro Pires Goulart
  • Teixeira, Mauro Martins
  • Queiroz-Junior, Celso Martins
  • Costa, Vivian Vasconcelos
Type
Published Article
Journal
Journal of Virology
Publisher
American Society for Microbiology
Publication Date
Jan 03, 2024
Volume
98
Issue
1
Identifiers
DOI: 10.1128/jvi.01102-23
Source
ASM Journals
Keywords
License
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Abstract

This work demonstrates the role of the CCL2/CCR2 axis in MAYV-induced disease. The infection of wild-type (WT) C57BL/6J and CCR2−/− mice was associated with high levels of CCL2, an important chemoattractant involved in the recruitment of macrophages, the main precursor of osteoclasts. In the absence of the CCR2 receptor, there is a mitigation of macrophage migration to the target organs of infection and protection of these mice against bone loss induced by MAYV infection. Much evidence has shown that host immune response factors contribute significantly to the tissue damage associated with alphavirus infections. Thus, this work highlights molecular and cellular targets involved in the pathogenesis of arthritis triggered by MAYV and identifies novel therapeutic possibilities directed to the host inflammatory response unleashed by MAYV.

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