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[Esophageal tumor induction in monkeys].

Authors
Type
Published Article
Journal
Voprosy onkologii
Publication Date
Volume
38
Issue
4
Pages
458–464
Identifiers
PMID: 1300741
Source
Medline
License
Unknown

Abstract

The experiment used eight monkeys who had received such esophagotropic carcinogens as ethyl ester of N-nitrososarcosine and methyl-N-benzyl-N-nitrosamine. The animals were followed for 4 years. The former agent failed to induce cancer where as 3 monkeys who had received methyl-N-benzyl-N-nitrosamine in the total dose of 600, 625 and 720 mg developed esophageal tumors (papilloma-2 and squamous cell carcinoma-1) at days 527, 725 and 880 after the start of treatment. The biological and histological features of the tumors were close to those of their human counterparts.

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