Affordable Access

[Esophageal tumor induction in monkeys].

Authors
  • Beniashvili, D Sh
  • Aleksandrov, V A
  • Bardadze, K I
  • Bespalov, V G
  • Petrov, A S
  • Sartaniia, M S
Type
Published Article
Journal
Voprosy onkologii
Publication Date
Jan 01, 1992
Volume
38
Issue
4
Pages
458–464
Identifiers
PMID: 1300741
Source
Medline
License
Unknown

Abstract

The experiment used eight monkeys who had received such esophagotropic carcinogens as ethyl ester of N-nitrososarcosine and methyl-N-benzyl-N-nitrosamine. The animals were followed for 4 years. The former agent failed to induce cancer where as 3 monkeys who had received methyl-N-benzyl-N-nitrosamine in the total dose of 600, 625 and 720 mg developed esophageal tumors (papilloma-2 and squamous cell carcinoma-1) at days 527, 725 and 880 after the start of treatment. The biological and histological features of the tumors were close to those of their human counterparts.

Report this publication

Statistics

Seen <100 times