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The Escherichia coli MarA protein regulates the ycgZ ‐ ymgABC operon to inhibit biofilm formation

Authors
  • Kettles, Rachel A.1
  • Tschowri, Natalia2
  • Lyons, Kevin J.1
  • Sharma, Prateek1
  • Hengge, Regine2
  • Webber, Mark A.3
  • Grainger, David C.1
  • 1 University of Birmingham, UK , (United Kingdom)
  • 2 Humboldt‐Universität zu Berlin, Germany , (Germany)
  • 3 Norwich Research Park, UK , (United Kingdom)
Type
Published Article
Journal
Molecular Microbiology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Sep 29, 2019
Volume
112
Issue
5
Pages
1609–1625
Identifiers
DOI: 10.1111/mmi.14386
PMID: 31518447
PMCID: PMC6900184
Source
PubMed Central
License
Unknown
External links

Abstract

Expression of the m ultiple a ntibiotic r esistance a ctivator (MarA) protein can give rise to clinically relevant drug resistance in Escherichia coli . Counterintuitively, we showed that MarA production inhibits the formation of biofilms. Inhibition is mediated by the activation of the ycgZ ‐ ymgABC operon. To activate these genes, MarA acts selectively thus enhancing transcription by RNAP associated with the σ70 but not with the σ38 factor.

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