[Escherichia coli L-asparaginase induces phosphorylation of endogenous polypeptides in human immune cells].
- Published Article
- Publication Date
Dec 01, 1999
Escherichia coli L-asparaginase, binds the plasma membrane in normal human immune cells, catalyzing the L-asparagine substrate. The products of its activity: aspartate and NH4+ modify the extracellular environment, particularly the latter since it could diffuse into the cytosol and modify the pH, which would activate signal transduction pathways associated with the phosphorylation of substrates.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/10822757