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[Escherichia coli L-asparaginase induces phosphorylation of endogenous polypeptides in human immune cells].

Authors
  • Mercado, L
  • Arenas, G
Type
Published Article
Journal
Sangre
Publication Date
Dec 01, 1999
Volume
44
Issue
6
Pages
438–442
Identifiers
PMID: 10822757
Source
Medline
License
Unknown

Abstract

Escherichia coli L-asparaginase, binds the plasma membrane in normal human immune cells, catalyzing the L-asparagine substrate. The products of its activity: aspartate and NH4+ modify the extracellular environment, particularly the latter since it could diffuse into the cytosol and modify the pH, which would activate signal transduction pathways associated with the phosphorylation of substrates.

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