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ES cell technology: an introduction to genetic manipulation, differentiation and therapeutic cloning.

Authors
Type
Published Article
Journal
Advanced Drug Delivery Reviews
0169-409X
Publisher
Elsevier
Publication Date
Volume
57
Issue
13
Pages
1904–1917
Identifiers
PMID: 16253387
Source
Medline

Abstract

ES cells are extraordinary cells, capable of proliferating in a pluripotent state indefinitely and of differentiating spontaneously into all cell types in vivo and many in vitro. However, the manipulation and modification of ES cells by processes such as directed differentiation and genetic modification have placed ES cells at the forefront of many biological studies and could lead to their application in biopharmaceutical areas such as cellular therapy and drug screening. Here we describe some of the ES cell based technologies that have lead to this realisation of ES cell potential.

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