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Erythropoietin increases survival and attenuates fulminant hepatic failure injury induced by D-galactosamine/lipopolysaccharide in mice.

Authors
  • Ben-Ari, Ziv
  • Zilbermints, Veacheslav
  • Pappo, Orit
  • Avlas, Orna
  • Sharon, Eran
  • Greif, Franklin
  • Cheporko, Yelena
  • Ravid, Amiram
  • Shapiro, Rivka
  • Hochhauser, Edith
Type
Published Article
Journal
Transplantation Journal
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jul 15, 2011
Volume
92
Issue
1
Pages
18–24
Identifiers
DOI: 10.1097/TP.0b013e31821cdea5
PMID: 21516061
Source
Medline
License
Unknown

Abstract

The administration of rhEPO brought about increased survival and attenuation of the hepatic injury. This was associated with decreased hepatic NF-κB and JNK activation and thus TNF-α and IL-1β levels. These findings have important implications for the potential use of rhEPO in FHF.

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