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Erlotinib and pantoprazole: a relevant interaction or not?

Authors
  • Ter Heine, Rob
  • Fanggiday, James C
  • Lankheet, Nienke A G
  • Beijnen, Jos H
  • Van Der Westerlaken, Monique M L
  • Staaks, Gerald H A
  • Malingré, Mirte M
Type
Published Article
Journal
British Journal of Clinical Pharmacology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Dec 01, 2010
Volume
70
Issue
6
Pages
908–911
Identifiers
DOI: 10.1111/j.1365-2125.2010.03748.x
PMID: 21175447
Source
Medline
License
Unknown

Abstract

More studies are needed to assess the dose dependency of the interaction between pantoprazole and erlotinib. Furthermore, we advise to monitor closely erlotinib plasma concentrations and adjust the erlotinib dose accordingly when a clinically relevant interaction is suspected and no proper dosing guidelines are available.

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