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Equine mesenchymal stromal cells from different tissue sources display comparable immune-related gene expression profiles in response to interferon gamma (IFN)-γ.

Authors
  • Cassano, Jennifer M1
  • Fortier, Lisa A2
  • Hicks, Rebecca B3
  • Harman, Rebecca M4
  • Van de Walle, Gerlinde R5
  • 1 Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14850, USA. Electronic address: [email protected]
  • 2 Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14850, USA. Electronic address: [email protected]
  • 3 Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14850, USA. Electronic address: [email protected]
  • 4 Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14850, USA. Electronic address: [email protected]
  • 5 Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14850, USA. Electronic address: [email protected]
Type
Published Article
Journal
Veterinary immunology and immunopathology
Publication Date
Aug 01, 2018
Volume
202
Pages
25–30
Identifiers
DOI: 10.1016/j.vetimm.2018.06.008
PMID: 30078595
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Mesenchymal stromal cells (MSC) have the therapeutic potential to decrease inflammation due to their immunomodulatory properties. They can be isolated from various tissue sources such as bone marrow, adipose tissue, and blood, but it is unknown how the tissue source of origin affects the responses of MSC to inflammatory stimuli. Here, we conceptually addressed this question by evaluating the immune-related gene expression profiles of equine MSC from different tissue sources in response to interferon gamma (IFN-γ) stimulation, with the goal to determine if there is a preferable MSC source for clinical application in an inflammatory environment. The salient findings from this initial study were that the baseline expression of all immune related genes analyzed, with the exception of prostaglandin-endoperoxide synthase 2 (PTGS2), was variable in MSC depending on tissue source. Following IFN-γ stimulation, however, gene expression profiles became more similar across all tissue sources, suggesting that MSC from different sources will likely respond similarly in an inflammatory environment when used clinically. Copyright © 2018 Elsevier B.V. All rights reserved.

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