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Epstein-Barr Virus-Negative Diffuse Large B-Cell Post-transplant Lymphoma in an Epstein-Barr Virus-Positive Recipient

Authors
  • Lee, Charlotte1
  • Vincentelli, Helena1
  • Visuri, Jenni1
  • Knight, Simon2, 3
  • Ploeg, Rutger2
  • 1 Medical Sciences Division, University of Oxford, Oxford, GBR
  • 2 Nuffield Department of Surgical Sciences, University of Oxford, Oxford, GBR
  • 3 Oxford Transplant Centre, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford, GBR
Type
Published Article
Journal
Cureus
Publisher
Cureus, Inc.
Publication Date
Sep 20, 2021
Volume
13
Issue
9
Identifiers
DOI: 10.7759/cureus.18134
PMID: 34567913
PMCID: PMC8454600
Source
PubMed Central
Keywords
Disciplines
  • Transplantation
License
Unknown
External links

Abstract

Post-transplant lymphoproliferative disease (PTLD) can arise as a complication after solid organ transplantation. Epstein-Barr virus (EBV) infection is a known risk factor and is known to drive disease manifestation. PTLD can occur in EBV-negative recipients and with EBV-negative donor organs, however, EBV-negative PTLD pathogenesis is unknown. Here, we present PTLD presenting as intussusception in a patient with a historic simultaneous pancreas-kidney transplant (SPK). This case study presents the first documented case of EBV-negative post-transplant lymphoproliferative disease in an EBV-seropositive SPK recipient from an EBV-positive donor. Here we describe the diagnosis and management of this patient, discuss the differences between EBV positive and negative driven post-transplant lymphoproliferative disease, and highlight areas of research opportunity in the latter.

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