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Epstein-Barr virus EBNA1 protein regulates viral latency through effects on let-7 microRNA and dicer.

Authors
  • Mansouri, Sheila
  • Pan, Qun
  • Blencowe, Benjamin J
  • Claycomb, Julie M
  • Frappier, Lori
Type
Published Article
Journal
Journal of Virology
Publisher
American Society for Microbiology
Publication Date
Oct 01, 2014
Volume
88
Issue
19
Pages
11166–11177
Identifiers
DOI: 10.1128/JVI.01785-14
PMID: 25031339
Source
Medline
License
Unknown

Abstract

The EBNA1 protein of Epstein-Barr virus (EBV) contributes in multiple ways to the latent mode of EBV infection that leads to lifelong infection. In this study, we identify a mechanism by which EBNA1 helps to maintain EBV infection in a latent state. This involves induction of a family of microRNAs (let-7 miRNAs) that in turn decreases the level of the cellular protein Dicer. We demonstrate that let-7 miRNAs inhibit the reactivation of latent EBV, providing an explanation for our previous observation that EBNA1 promotes latency. In addition, since decreased levels of Dicer have been associated with metastatic potential, EBNA1 may increase metastases by downregulating Dicer.

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