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E-PSMA: the EANM standardized reporting guidelines v1.0 for PSMA-PET

Authors
  • Ceci, Francesco1
  • Oprea-Lager, Daniela E.2
  • Emmett, Louise3, 4
  • Adam, Judit A.5
  • Bomanji, Jamshed6
  • Czernin, Johannes7
  • Eiber, Matthias8
  • Haberkorn, Uwe9
  • Hofman, Michael S.10, 11
  • Hope, Thomas A.12
  • Kumar, Rakesh13
  • Rowe, Steven P.14
  • Schwarzenboeck, Sarah M.15
  • Fanti, Stefano16
  • Herrmann, Ken17
  • 1 University of Turin,
  • 2 Cancer Center Amsterdam,
  • 3 University of New South Wales,
  • 4 St. Vincent’s Hospital Sydney,
  • 5 University of Amsterdam,
  • 6 University College London Hospitals NHS Foundation Trust,
  • 7 University of California Los Angeles,
  • 8 Technische Universität München,
  • 9 Heidelberg University Hospital,
  • 10 Peter MacCallum Cancer Centre,
  • 11 University of Melbourne,
  • 12 University of California San Francisco,
  • 13 All India Institute of Medical Sciences,
  • 14 Johns Hopkins University School of Medicine,
  • 15 Rostock University Medical Centre,
  • 16 University of Bologna,
  • 17 University Hospital Essen,
Type
Published Article
Journal
European Journal of Nuclear Medicine
Publisher
Springer-Verlag
Publication Date
Feb 19, 2021
Volume
48
Issue
5
Pages
1626–1638
Identifiers
DOI: 10.1007/s00259-021-05245-y
PMID: 33604691
PMCID: PMC8113168
Source
PubMed Central
Keywords
Disciplines
  • Guidelines
License
Unknown

Abstract

Rationale The development of consensus guidelines for interpretation of Prostate-Specific Membrane Antigen (PSMA)-Positron Emission Tomography (PET) is needed to provide more consistent reports in clinical practice. The standardization of PSMA-PET interpretation may also contribute to increasing the data reproducibility within clinical trials. Finally, guidelines in PSMA-PET interpretation are needed to communicate the exact location of findings to referring physicians, to support clinician therapeutic management decisions. Methods A panel of worldwide experts in PSMA-PET was established. Panelists were selected based on their expertise and publication record in the diagnosis or treatment of PCa, in their involvement in clinical guidelines and according to their expertise in the clinical application of radiolabeled PSMA inhibitors. Panelists were actively involved in all stages of a modified, nonanonymous, Delphi consensus process. Results According to the findings obtained by modified Delphi consensus process, panelist recommendations were implemented in a structured report for PSMA-PET. Conclusions The E-PSMA standardized reporting guidelines, a document supported by the European Association of Nuclear Medicine (EANM), provide consensus statements among a panel of experts in PSMA-PET imaging, to develop a structured report for PSMA-PET in prostate cancer and to harmonize diagnostic interpretation criteria. Supplementary Information The online version contains supplementary material available at 10.1007/s00259-021-05245-y.

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