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Epitope-optimized alpha-fetoprotein genetic vaccines prevent carcinogen-induced murine autochthonous hepatocellular carcinoma.

Authors
  • Hong, Yuan
  • Peng, Yibing
  • Guo, Z Sheng
  • Guevara-Patino, Jose
  • Pang, Junfeng
  • Butterfield, Lisa H
  • Mivechi, Nahid F
  • Munn, David H
  • Bartlett, David L
  • He, Yukai
Type
Published Article
Journal
Hepatology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Apr 01, 2014
Volume
59
Issue
4
Pages
1448–1458
Identifiers
DOI: 10.1002/hep.26893
PMID: 24122861
Source
Medline
License
Unknown

Abstract

Epitope-optimization is required to break immune tolerance and potently activate AFP-specific CD8 T cells, generating effective antitumor effect to prevent clinically relevant carcinogen-induced autochthonous HCC in mice. Our study provides a practical roadmap to develop effective human HCC vaccines that may result in an improved outcome compared to the current HCC vaccines based on wild-type AFP.

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