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Epithelialization in Wound Healing: A Comprehensive Review.

Authors
  • I, Pastar
  • O, Stojadinovic
  • Nc, Yin
  • H, Ramirez
  • Ag, Nusbaum
  • A, Sawaya
  • Sb, Patel
  • L, Khalid
  • Rivkah Isseroff
  • M, Tomic-Canic
Type
Published Article
Journal
Advances in Wound Care
Publisher
Mary Ann Liebert
Publication Date
Jul 17, 2014
Volume
3
Issue
7
Pages
445–445
Identifiers
DOI: 10.1089/wound.2013.0473
PMID: 25032064
PMCID: PMC4086220
Source
Isseroff Lab dermatology-ucdavis
License
Green

Abstract

Significance: Keratinocytes, a major cellular component of the epidermis, are responsible for restoring the epidermis after injury through a process termed epithelialization. This review will focus on the pivotal role of keratinocytes in epithelialization, including cellular processes and mechanisms of their regulation during re-epithelialization, and their cross talk with other cell types participating in wound healing. Recent Advances: Discoveries in epidermal stem cells, keratinocyte immune function, and the role of the epidermis as an independent neuroendocrine organ will be reviewed. Novel mechanisms of gene expression regulation important for re-epithelialization, including microRNAs and histone modifications, will also be discussed. Critical Issues: Epithelialization is an essential component of wound healing used as a defining parameter of a successful wound closure. A wound cannot be considered healed in the absence of re-epithelialization. The epithelialization process is impaired in all types of chronic wounds. Future Directions: A comprehensive understanding of the epithelialization process will ultimately lead to the development of novel therapeutic approaches to promote wound closure.

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