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Epithelial stem cells and intestinal cancer

Authors
  • Tan, Shawna
  • Barker, Nick1, 2, 3
  • 1 A-STAR Institute of Medical Biology
  • 2 Centre for Regenerative Medicine
  • 3 Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore
Type
Published Article
Journal
Seminars in Cancer Biology
Publication Date
Jan 01, 2014
Identifiers
DOI: 10.1016/j.semcancer.2014.02.005
Source
Elsevier
Keywords
License
Unknown

Abstract

The mammalian intestine is comprised of an epithelial layer that serves multiple functions in order to maintain digestive activity as well as intestinal homeostasis. This epithelial layer contains highly proliferative stem cells which facilitate its characteristic rapid regeneration. How these stem cells contribute to tissue repair and normal homeostasis are actively studied, and while we have a greater understanding of the molecular mechanisms and cellular locations that underlie stem cell regulation in this tissue, much still remains undiscovered. This review describes epithelial stem cells in both intestinal and non-intestinal tissues, as well as the strategies that have been used to further characterize the cells. Through a discussion of the current understanding of intestinal self-renewal and tissue regeneration in response to injury, we focus on how dysregulation of critical signaling pathways results in potentially oncogenic aberrations, and highlight issues that should be addressed in order for effective intestinal cancer therapies to be devised.

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