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Epithelial Pten controls acute lung injury and fibrosis by regulating alveolar epithelial cell integrity.

Authors
  • Miyoshi, Kahori
  • Yanagi, Shigehisa
  • Kawahara, Kohichi
  • Nishio, Miki
  • Tsubouchi, Hironobu
  • Imazu, Yoshifumi
  • Koshida, Ryusuke
  • Matsumoto, Nobuhiro
  • Taguchi, Akiko
  • Yamashita, Shu-ichi
  • Suzuki, Akira
  • Nakazato, Masamitsu
Type
Published Article
Journal
American Journal of Respiratory and Critical Care Medicine
Publisher
American Thoracic Society
Publication Date
Feb 01, 2013
Volume
187
Issue
3
Pages
262–275
Identifiers
DOI: 10.1164/rccm.201205-0851OC
PMID: 23239155
Source
Medline
License
Unknown

Abstract

Our results highlight epithelial Pten as a crucial gatekeeper controlling ALI and lung fibrosis by modulating AEC integrity, and the Pten/PI3K/Akt pathway as a potential therapeutic target in these intractable diseases.

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