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Epithelial-mesenchymal interactions in breast cancer: evidence for a role of nuclear localized β-catenin in carcinoma-associated fibroblasts.

Authors
  • Verghese, Eldo T
  • Shenoy, Hrishikesh
  • Cookson, Victoria J
  • Green, Caroline A
  • Howarth, Jo
  • Partanen, R H
  • Pollock, Steven
  • Waterworth, Alison
  • Speirs, Valerie
  • Hughes, Thomas A
  • Hanby, Andrew M
Type
Published Article
Journal
Histopathology
Publication Date
Oct 01, 2011
Volume
59
Issue
4
Pages
609–618
Identifiers
DOI: 10.1111/j.1365-2559.2011.03917.x
PMID: 22014042
Source
Medline
License
Unknown

Abstract

The presence of fibroblasts with nuclear β-catenin in tumours is a good prognostic indicator, although in the context of tissue culture models these cells can increase the growth and metastatic potential of cancer cells. These apparently paradoxical observations underline the complexity of epithelial-stromal signalling within tumours and highlight an area for further study.

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