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Epistatic interactions between HLA-DRB1 and interleukin 4, but not interferon-gamma, increase susceptibility to giant cell arteritis.

Authors
  • Amoli, Mahsa M
  • Gonzalez-Gay, Miguel A
  • Zeggini, Eleftheria
  • Salway, Fiona
  • Garcia-Porrua, Carlos
  • Ollier, William E R
Type
Published Article
Journal
The Journal of rheumatology
Publication Date
Dec 01, 2004
Volume
31
Issue
12
Pages
2413–2417
Identifiers
PMID: 15570643
Source
Medline
License
Unknown

Abstract

Our results suggest an association with IL-4 gene polymorphism that is dependent on HLA-DRB1 genotype in GCA susceptible individuals. These data indicate an interaction between HLA-DRB1 and IL-4 that contributes to pronounced disease susceptibility.

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