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Epipolythiodiketopiperazines from the Marine Derived Fungus Dichotomomyces cejpii with NF-κB Inhibitory Potential

Authors
Type
Published Article
Journal
Marine Drugs
Publisher
MDPI AG
Publication Date
Aug 05, 2015
Volume
13
Issue
8
Identifiers
DOI: 10.3390/md13084950
Source
LBMCC
Keywords
License
Green

Abstract

The Ascomycota Dichotomomyces cejpii was isolated from the marine sponge Callyspongia cf. C. flammea. A new gliotoxin derivative, 6-acetylmonodethiogliotoxin (1) was obtained from fungal extracts. Compounds 2 and 3, methylthio-gliotoxin derivatives were formerly only known as semi-synthetic compounds and are here described as natural products. Additionally the polyketide heveadride (4) was isolated. Compounds 1, 2 and 4 dose-dependently down-regulated TNFα-induced NF-κB activity in human chronic …

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