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Epigenomics of leukemia: from mechanisms to therapeutic applications

Authors
Type
Published Article
Journal
Epigenomics
Publisher
Future Medicine
Publication Date
Oct 22, 2011
Volume
3
Issue
5
Pages
609–609
Identifiers
DOI: 10.2217/epi.11.73
Source
LBMCC
Keywords
License
Yellow

Abstract

Leukemogenesis is a multistep process in which successive transformational events enhance the ability of a clonal population arising from hematopoietic progenitor cells to proliferate, differentiate and survive. Clinically and pathologically, leukemia is subdivided into four main categories: chronic lymphocytic leukemia, chronic myeloid leukemia, acute lymphocytic leukemia and acute myeloid leukemia. Leukemia has been previously considered only as a genetic disease. However, in recent years, significant advances have been made in the elucidation of the leukemogenesis-associated processes. Thus, we have come to understand that epigenetic alterations including DNA methylation, histone modifications and miRNA are involved in the permanent changes of gene expression controlling the leukemia phenotype. In this article, we will focus on the epigenetic defects associated with leukemia and their implications as biomarkers for diagnostic, prognostic and therapeutic applications.

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