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Epigenetics of nicotine: another nail in the coughing.

Authors
Type
Published Article
Journal
Science Translational Medicine
1946-6242
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
Volume
3
Issue
107
Identifiers
DOI: 10.1126/scitranslmed.3003278
PMID: 22049068
Source
Medline

Abstract

In a mouse model, chronic nicotine exposure before cocaine use exacerbated the epigenetic, gene-expression, electrophysiological, and behavioral effects that occur during the transition from acute to chronic responses to cocaine that have been linked with the addictive process. Nicotine enhancement of the effects can be mimicked with an inhibitor of chromatin-modifying enzymes (class I and II histone deacetylases). These findings may spur the discovery of therapeutics for the treatment of addiction.

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