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Epigenetics in age-related macular degeneration: new discoveries and future perspectives

Authors
  • Gemenetzi, M.1
  • Lotery, A. J.2
  • 1 NIHR Biomedical Research Centre At Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology,
  • 2 University of Southampton,
Type
Published Article
Journal
Cellular and Molecular Life Sciences
Publisher
Springer-Verlag
Publication Date
Jan 02, 2020
Volume
77
Issue
5
Pages
807–818
Identifiers
DOI: 10.1007/s00018-019-03421-w
PMID: 31897542
PMCID: PMC7058675
Source
PubMed Central
Keywords
License
Unknown

Abstract

The study of epigenetics has explained some of the ‘missing heritability’ of age-related macular degeneration (AMD). The epigenome also provides a substantial contribution to the organisation of the functional retina. There is emerging evidence of specific epigenetic mechanisms associated with AMD. This ‘AMD epigenome’ may offer the chance to develop novel AMD treatments.

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