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Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans

Authors
  • Yates, Kathleen B.1, 2, 3
  • Tonnerre, Pierre4, 5
  • Martin, Genevieve E.6, 7
  • Gerdemann, Ulrike1
  • Al Abosy, Rose1
  • Comstock, Dawn E.1, 8
  • Weiss, Sarah A.1, 8
  • Wolski, David4
  • Tully, Damien C.9, 10
  • Chung, Raymond T.4
  • Allen, Todd M.9
  • Kim, Arthur Y.4
  • Fidler, Sarah11, 12
  • Fox, Julie13, 14
  • Frater, John6, 15
  • Lauer, Georg M.4
  • Haining, W. Nicholas1, 16
  • Sen, Debattama R.1, 2
  • 1 Dana–Farber Cancer Institute, Boston, MA, USA , Boston (United States)
  • 2 Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA , Charlestown (United States)
  • 3 Broad Institute of MIT and Harvard, Cambridge, MA, USA , Cambridge (United States)
  • 4 Massachusetts General Hospital, Boston, MA, USA , Boston (United States)
  • 5 Inserm U976, Institut de Recherche Saint-Louis, Paris, France , Paris (France)
  • 6 University of Oxford, Oxford, UK , Oxford (United Kingdom)
  • 7 Monash University, Melbourne, Australia , Melbourne (Australia)
  • 8 Harvard Medical School, Boston, MA, USA , Boston (United States)
  • 9 Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA , Cambridge (United States)
  • 10 London School of Hygiene and Tropical Medicine, London, UK , London (United Kingdom)
  • 11 Wright Fleming Institute, Imperial College, London, UK , London (United Kingdom)
  • 12 Imperial College National Institute for Health Research Biomedical Research Centre, London, UK , London (United Kingdom)
  • 13 Guy’s and St Thomas’ NHS Foundation Trust, London, UK , London (United Kingdom)
  • 14 King’s College National Institute for Health Research Biomedical Research Centre, London, UK , London (United Kingdom)
  • 15 Oxford National Institute for Health Research Biomedical Research Centre, Oxford, UK , Oxford (United Kingdom)
  • 16 Merck Research Laboratories, Boston, MA, USA , Boston (United States)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Jul 26, 2021
Volume
22
Issue
8
Pages
1020–1029
Identifiers
DOI: 10.1038/s41590-021-00979-1
Source
Springer Nature
Disciplines
  • article
License
Yellow

Abstract

The degree of plasticity in the epigenetic landscape of exhausted T cells has been unclear. Sen and colleagues find that exhausted CD8+ T cells demonstrate a stable core epigenetic exhaustion signature that persists independent of inflammation or viral antigen.

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