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The epigenetic impacts of endocrine disruptors on female reproduction across generations†.

Authors
  • Rattan, Saniya1
  • Flaws, Jodi A1
  • 1 Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Illinois, USA.
Type
Published Article
Journal
Biology of Reproduction
Publisher
Oxford University Press
Publication Date
Sep 01, 2019
Volume
101
Issue
3
Pages
635–644
Identifiers
DOI: 10.1093/biolre/ioz081
PMID: 31077281
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Humans and animals are repeatedly exposed to endocrine disruptors, many of which are ubiquitous in the environment. Endocrine disruptors interfere with hormone action; thus, causing non-monotonic dose responses that are atypical of standard toxicant exposures. The female reproductive system is particularly susceptible to the effects of endocrine disruptors. Likewise, exposures to endocrine disruptors during developmental periods are particularly concerning because programming during development can be adversely impacted by hormone level changes. Subsequently, developing reproductive tissues can be predisposed to diseases in adulthood and these diseases can be passed down to future generations. The mechanisms of action by which endocrine disruptors cause disease transmission to future generations are thought to include epigenetic modifications. This review highlights the effects of endocrine disruptors on the female reproductive system, with an emphasis on the multi- and transgenerational epigenetic effects of these exposures. © The Author(s) 2019. Published by Oxford University Press on behalf of Society for the Study of Reproduction.

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