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Epigenetic control of skin differentiation genes by phytocannabinoids.

Authors
  • Pucci, Mariangela
  • Rapino, Cinzia
  • Di Francesco, Andrea
  • Dainese, Enrico
  • D'Addario, Claudio
  • Maccarrone, Mauro
Type
Published Article
Journal
British Journal of Pharmacology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Oct 01, 2013
Volume
170
Issue
3
Pages
581–591
Identifiers
DOI: 10.1111/bph.12309
PMID: 23869687
Source
Medline
Keywords
License
Unknown

Abstract

These findings show that the phytocannabinoids cannabidiol and cannabigerol are transcriptional repressors that can control cell proliferation and differentiation. This indicates that they (especially cannabidiol) have the potential to be lead compounds for the development of novel therapeutics for skin diseases.

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