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Epigenetic alterations as a universal feature of cancer hallmarks and a promising target for personalized treatments

Authors
Type
Published Article
Journal
Current Topics in Medicinal Chemistry
Publisher
Bentham Science
Publication Date
Nov 10, 2015
Volume
16
Issue
7
Identifiers
DOI: 10.2174/1568026615666150825141330
Source
LBMCC
Keywords
License
Yellow

Abstract

Despite considerable scientific progress, the burden of cancer in our society remains a major public health problem. Tumorigenesis is recognized as a complex and multistep process that involves the accumulation of successive transformational events with multi-factorial etiology. Nevertheless, such events result in the acquisition of key hallmark characteristics that are shared by all cancer cells. Accumulating evidence indicates that, besides genetic alterations, epigenetic mechanisms (heritable changes in gene …

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