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Epidermal growth factor up-regulates sodium-glucose cotransport in enterocyte models in the presence of cholera toxin.

Authors
  • Mehta, D I
  • Horváth, K
  • Chanasongcram, S
  • Hill, I D
  • Panigrahi, P
Type
Published Article
Journal
JPEN. Journal of parenteral and enteral nutrition
Publication Date
Jan 01, 1997
Volume
21
Issue
4
Pages
185–191
Identifiers
PMID: 9252942
Source
Medline
License
Unknown

Abstract

Differentiated Caco-2 cells have two kinetically distinct sodium-glucose cotransporters. Short-term incubation of Caco-2 cells with EGF resulted in an up-regulation of sodium-glucose cotransport and subsequent increase in Na+/K(+)-ATPase activity. The effect of basolaterally applied EGF was more significant with or without incubation with cholera toxin. The early effect of EGF on glucose and sodium cotransport may have important therapeutic implications in diarrhea and dehydration states. The in vitro model described here uses a homogeneous cell population and provides a versatile system for uptake and transport studies.

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