Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Epidemiology and management of Buruli ulcer.

Authors
  • 1
  • 1 Department of Infectious Diseases, Austin Hospital, Victoria 3084, Australia. , (Australia)
Type
Published Article
Journal
Expert Review of Anti-infective Therapy
1744-8336
Publisher
"Informa Healthcare (Expert Reviews, LTD)"
Publication Date
Volume
12
Issue
7
Pages
855–865
Identifiers
DOI: 10.1586/14787210.2014.910113
PMID: 24918117
Source
Medline
Keywords
License
Unknown

Abstract

Buruli ulcer (Mycobacterium ulcerans infection) is a neglected tropical disease of skin and subcutaneous tissue that can result in long-term cosmetic and functional disability. It is a geographically restricted infection but transmission has been reported in endemic areas in more than 30 countries worldwide. The heaviest burden of disease lies in West and Sub-Saharan Africa where it affects children and adults in subsistence agricultural communities. Mycobacterium ulcerans infection is probably acquired via inoculation of the skin either directly from the environment or indirectly via insect bites. The environmental reservoir and exact route of transmission are not completely understood. It may be that the mode of acquisition varies in different parts of the world. Because of this uncertainty it has been nicknamed the 'mysterious disease'. The therapeutic approach has evolved in the past decade from aggressive surgical resection alone, to a greater focus on antibiotic therapy combined with adjunctive surgery.

Statistics

Seen <100 times