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Epidemiological overview of metastatic ovarian carcinoma: long-term experience of TOTSG database.

Authors
  • Kajiyama, Hiroaki1
  • Suzuki, Shiro1
  • Utsumi, Fumi1
  • Nishino, Kimihiro1
  • Niimi, Kaoru1
  • Mizuno, Mika2
  • Yoshikawa, Nobuhisa1
  • Kawai, Michiyasu3
  • Oguchi, Hidenori4
  • Mizuno, Kimio5
  • Yamamuro, Osamu6
  • Shibata, Kiyosumi7
  • Nagasaka, Tetsuro8
  • Kikkawa, Fumitaka1
  • 1 Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan. , (Japan)
  • 2 Department of Gynecologic Oncology, Aichi Cancer Center Hospital, Nagoya, Japan. , (Japan)
  • 3 Department of Obstetrics and Gynecology, Toyohashi Municipal Hospital, Toyohashi, Japan. , (Japan)
  • 4 Department of Obstetrics and Gynecology, Toyota Memorial Hospital, Toyota, Japan. , (Japan)
  • 5 Department of Obstetrics and Gynecology, Nagoya First Red-cross Hospital, Nagoya, Japan. , (Japan)
  • 6 Department of Obstetrics and Gynecology, Nagoya Second Red-cross Hospital, Nagoya, Japan. , (Japan)
  • 7 Department of Obstetrics and Gynecology, Bantane Hospital, Fujita Health University, Nagoya, Japan. , (Japan)
  • 8 Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan. , (Japan)
Type
Published Article
Journal
Nagoya journal of medical science
Publication Date
May 01, 2019
Volume
81
Issue
2
Pages
193–198
Identifiers
DOI: 10.18999/nagjms.81.2.193
PMID: 31239587
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Malignant ovarian neoplasm is one of the most lethal malignancies among cancers of the female reproductive system. Occasionally, these tumors originate from non-ovarian organs as metastatic lesions since the ovary is a frequent metastatic target of many cancers. However, there limited clinical information on metastatic ovarian carcinoma (MOC) and its hallmarks are unknown. During the period of 1986-2015, 4,284 patients with malignant ovarian neoplasm were identified using the Tokai Ovarian Tumor Study Group (TOTSG) database. Of these, excluding borderline malignant tumor, 3,478 patients with malignant ovarian cancer were extracted. The pathological slides were evaluated under central pathological review. Among them, a total of 143 (4.1%) patients with MOC were identified. The median age of patients with MOC was 54 (29-82) years. The most and second most frequent original tumors were colorectal (43%, N=62) and gastric (29%, N=42) carcinoma, respectively. The rates of carcinoma of the appendix, breast, and pancreas were 8, 6, and 4%, respectively. This is the one of the largest studies clarifying the rates of MOC among malignant ovarian neoplasms. Although the rate is low, we should keep in mind that MOC, particularly from colorectal and gastric cancer should be considered when encountering clinical practice of ovarian cancer.

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