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Epidemiological and clinical profile, and survival of patients followed for breast cancer between 2010 and 2015 at the Yaounde General Hospital, Cameroon

Authors
  • Zingue, Stéphane1, 2, 3
  • Atenguena, Etienne Okobalemba2, 3, 4
  • Zingue, Laure Leka2
  • Tueche, Alain Brice5
  • Njamen, Dieudonné5
  • Nkoum, Alexandre Benjamin3
  • Ndom, Paul2, 4
  • 1 Department of Medical and Biomedical Engineering, Higher Technical Teachers´ Training College, University of Yaounde I, P.O. Box 886 Ebolowa, Cameroon,
  • 2 Oncology Division, Yaoundé General Hospital, Yaoundé, Cameroon,
  • 3 School of Health Sciences, Catholic University of Central Africa, Yaoundé, Cameroon,
  • 4 Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon,
  • 5 Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812 Yaounde, Cameroon
Type
Published Article
Journal
Pan African Medical Journal
Publisher
Pan African Medical Journal
Publication Date
Jul 07, 2021
Volume
39
Identifiers
DOI: 10.11604/pamj.2021.39.182.26866
PMID: 34466203
PMCID: PMC8378266
Source
PubMed Central
Keywords
Disciplines
  • Research
License
Unknown

Abstract

Introduction approximately 6000 Cameroonian women died of cancer in 2018, and the breast is the most affected with 2625 new cases. The aim of this study was to establish a pattern of malignant breast tumours in Yaoundé (Cameroon). Methods this study was a descriptive and analytical retrospective study of breast cancer between January 2010 and December 2015 in Yaoundé General Hospital (YGH) after the Institutional ethics committee approval. The variables studied were the socio-demographic characteristics, risk factors for breast cancer, types of tumours and type of treatments. The 5-year survival was analyzed by the Kaplan-Meier method. The adjusted hazard ratios and their 95% confidence intervals were calculated to assess the association between studied variables and patient survival through the cox regression using SPSS 23 software. The difference was considered significant at p < 0.05. Results among the 344 files collected in this study, breast cancer patients were predominantly female (96.64%, n = 288) aged 45.39 ± 13.35 years, with invasive ductal carcinoma (68.03%, n = 270), located in the left breast (52%, n= 147). The average tumour size was ~6.5 ± 0.3 cm and diagnosed in grade II of Scarf Bloom Richardson (SBR) in 60% (n= 150) of cases. The 5-year survival was 43.3%. Factors associated with this poor survival were the religion (aHR 5.05, 95% CI: 1.57 - 16.25; p = 0.007 for animist and aHR 4.2, 95% CI: 1.53 - 11.46; p = 0.005 for protestant), location of the tumour (aHR 6.24, 95% CI: 1.58 - 24.60; p = 0.012), tumor height (aHR 0.21, 95% CI: 0.04 - 1.11; p = 0.011) and the time spent before medical treatment (aHR 5.12, 95% CI: 0.39 - 8.38; p = 0.011). Conclusion the young age, large tumour size and high histological grade in our studied population suggest a weak awareness of women about breast cancer. Action should be taken in early screening to improve the management of breast cancer in Cameroon.

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