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Epidemiologic survey of feline leukemia virus in domestic cats on Tsushima Island, Japan: management strategy for Tsushima leopard cats.

Authors
  • Makundi, Isaac1, 2, 3, 4, 5
  • Koshida, Yushi1, 2, 3, 4, 5
  • Kuse, Kyohei1, 2, 3, 4, 5
  • Hiratsuka, Takahiro1, 2, 3, 4, 5
  • Ito, Jumpei1, 2, 3, 4, 5
  • Baba, Takuya1, 2, 3, 4, 5
  • Watanabe, Shinya1, 2, 3, 4, 5
  • Kawamura, Maki1, 2, 3, 4, 5
  • Odahara, Yuka1, 2, 3, 4, 5
  • Miyake, Ariko1, 2, 3, 4, 5
  • Yamamoto, Hanae1, 2, 3, 4, 5
  • Kuniyoshi, Sawako1, 2, 3, 4, 5
  • Onuma, Manabu1, 2, 3, 4, 5
  • Nishigaki, Kazuo1, 2, 3, 4, 5
  • 1 Laboratory of Molecular Immunology and Infectious Disease, The United Graduate School of Veterinary Science, Yamaguchi University, Yoshida, Yamaguchi, Japan (Makundi, Watanabe, Kawamura, Nishigaki). , (Japan)
  • 2 Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan (Kuse, Hiratsuka, Ito, Baba, Odahara, Miyake, Nishigaki). , (Japan)
  • 3 Conservation and Animal Welfare Trust, Tsushima, Nagasaki, Japan (Koshida). , (Japan)
  • 4 Tsushima Rangers Office, Ministry of the Environment, Tsushima, Nagasaki, Japan (Yamamoto, Kuniyoshi). , (Japan)
  • 5 Ecological Genetics Analysis Section, Center for Environmental Biology and Ecosystem, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan (Onuma). , (Japan)
Type
Published Article
Journal
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Publication Date
Nov 01, 2017
Volume
29
Issue
6
Pages
889–895
Identifiers
DOI: 10.1177/1040638717725551
PMID: 28782421
Source
Medline
Keywords
License
Unknown

Abstract

The Tsushima leopard cat (TLC) Prionailurus bengalensis euptilurus, a subspecies of P. bengalensis, is designated a National Natural Monument of Japan, and lives only on Tsushima Island, Nagasaki Prefecture, Japan. TLCs are threatened by various infectious diseases. Feline leukemia virus (FeLV) causes a serious infectious disease with a poor prognosis in cats. Therefore, the transmission of FeLV from Tsushima domestic cats (TDCs) to TLCs may threaten the TLC population. We investigated the FeLV infection status of both TDCs and TLCs on Tsushima Island by screening blood samples for FeLV p27 antigen and using PCR to amplify the full-length FeLV env gene. The prevalence of FeLV was 6.4% in TDCs and 0% in TLCs. We also demonstrated that the virus can replicate in the cells of TLCs, suggesting its potential cross-species transmission. The viruses in TDCs were classified as genotype I/clade 3, which is prevalent on a nearby island, based on previous studies of FeLV genotypes and FeLV epidemiology. The FeLV viruses identified on Tsushima Island can be further divided into 2 lineages within genotype I/clade 3, which are geographically separated in Kamijima and Shimojima, indicating that FeLV may have been transmitted to Tsushima Island at least twice. Monitoring FeLV infection in the TDC and TLC populations is highly recommended as part of the TLC surveillance and management strategy.

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