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Epidemiologic characteristics and influencing factors of cluster infection of COVID-19 in Jiangsu Province

Authors
  • Ai, Jing1, 2
  • Shi, Naiyang2, 3
  • Shi, Yingying1
  • Xu, Ke1
  • Dai, Qigang1
  • Liu, Wendong1
  • Chen, Liling4
  • Wang, Junjun5
  • Gao, Qiang6
  • Ji, Hong1
  • Wu, Ying1
  • Huang, Haodi1
  • Zhao, Ziping7
  • Jin, Hui2, 3
  • Bao, Changjun1, 8
  • 1 Jiangsu Provincial Centre for Disease Control and Prevention, China , (China)
  • 2 Southeast University, China , (China)
  • 3 Ministry of Education, China , (China)
  • 4 Suzhou Centre for Disease Control and Prevention, China , (China)
  • 5 Nanjing Centre for Disease Control and Prevention, China , (China)
  • 6 Huaian Centre for Disease Control and Prevention, China , (China)
  • 7 Nanjing Medical University, China , (China)
  • 8 NHC Key Laboratory of Enteric Pathogenic Microbiology, China , (China)
Type
Published Article
Journal
Epidemiology and Infection
Publisher
Cambridge University Press
Publication Date
Feb 10, 2021
Volume
149
Identifiers
DOI: 10.1017/S0950268821000327
PMID: 33563364
PMCID: PMC7900655
Source
PubMed Central
Keywords
License
Green

Abstract

To understand the characteristics and influencing factors related to cluster infections in Jiangsu Province, China, we investigated case reports to explore transmission dynamics and influencing factors of scales of cluster infection. The effectiveness of interventions was assessed by changes in the time-dependent reproductive number ( R t ). From 25th January to 29th February, Jiangsu Province reported a total of 134 clusters involving 617 cases. Household clusters accounted for 79.85% of the total. The time interval from onset to report of index cases was 8 days, which was longer than that of secondary cases (4 days) ( χ 2 = 22.763, P < 0.001) and had a relationship with the number of secondary cases (the correlation coefficient ( r ) = 0.193, P = 0.040). The average interval from onset to report was different between family cluster cases (4 days) and community cluster cases (7 days) ( χ 2 = 28.072, P < 0.001). The average time interval from onset to isolation of patients with secondary infection (5 days) was longer than that of patients without secondary infection (3 days) ( F = 9.761, P = 0.002). Asymptomatic patients and non-familial clusters had impacts on the size of the clusters. The average reduction in the R t value in family clusters (26.00%, 0.26 ± 0.22) was lower than that in other clusters (37.00%, 0.37 ± 0.26) ( F = 4.400, P = 0.039). Early detection of asymptomatic patients and early reports of non-family clusters can effectively weaken cluster infections.

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