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EPI distortion correction for concurrent human brain stimulation and imaging at 3T.

Authors
  • Oh, Hyuntaek1
  • Kim, Jung Hwan1
  • Yau, Jeffrey M2
  • 1 Department of Neuroscience, Baylor College of Medicine, Houston, TX, 77030 USA.
  • 2 Department of Neuroscience, Baylor College of Medicine, Houston, TX, 77030 USA. Electronic address: [email protected]
Type
Published Article
Journal
Journal of neuroscience methods
Publication Date
Nov 01, 2019
Volume
327
Pages
108400–108400
Identifiers
DOI: 10.1016/j.jneumeth.2019.108400
PMID: 31434000
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Transcranial magnetic stimulation (TMS) can be paired with functional magnetic resonance imaging (fMRI) in concurrent TMS-fMRI experiments. These multimodal experiments enable causal probing of network architecture in the human brain which can complement alternative network mapping approaches. Critically, merely introducing the TMS coil into the scanner environment can sometimes produce substantial magnetic field inhomogeneities and spatial distortions which limit the utility of concurrent TMS-fMRI. We assessed the efficacy of point spread function corrected echo planar imaging (PSF-EPI) in correcting for the field inhomogeneities associated with a TMS coil at 3 T. In phantom and brain scans, we quantitatively compared the coil-induced distortion artifacts measured in EPI scans with and without PSF correction. We found that the application of PSF corrections to the EPI data significantly improved signal-to-noise and reduced distortions. In phantom scans with the PSF-EPI sequence, we also characterized the temporal profile of dynamic artifacts associated with TMS delivery and found that image quality remained high as long as the TMS pulse preceded the RF excitation pulses by at least 50 ms. Lastly, we validated the PSF-EPI sequence in human brain scans involving TMS and motor behavior as well as resting state fMRI scans. Our collective results demonstrate the potential benefits of PSF-EPI for concurrent TMS-fMRI when coil-related artifacts are a concern. The ability to collect high quality resting state fMRI data in the same session as the concurrent TMS-fMRI experiment offers a unique opportunity to interrogate network architecture in the human brain. Copyright © 2019 Elsevier B.V. All rights reserved.

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